Go beyond. Join the mission to discover the next generation of asthma treatments.
Participate in our clinical trial and help us learn if a potential new way of targeting asthma can give people control over their symptoms.
Our understanding of asthma is evolving
Participate in our clinical trial and help us learn if a potential new way of targeting asthma can give people control over their symptoms.
Some people living with asthma don’t think better control is possible. Developing new potential treatments could help control asthma and its symptoms.
If you participate in this clinical trial, you’ll receive care from a team of dedicated specialists. Tomorrow’s asthma breakthroughs are being developed in clinical trials today.
Asthma can be difficult to treat long term. Patients with moderate to severe asthma do not respond well to standard inhaled treatments and there is a need for more effective therapies to better control the symptoms [and causes] of asthma.
About this trial
We are working closely with doctors to conduct a clinical trial for people with moderate to severe asthma.
If in the last 12 months you’ve needed to take steroids for worsening asthma, then this clinical trial might be a good option for you.
We are studying a targeted [biologic] steroid-free potential treatment to see if it can safely and effectively help people with asthma to gain better control of their symptoms.
About the treatment being studied
Most advanced treatment options available for asthma today target one or two proteins within the immune system. We are studying a type of medicine called a trispecific that targets 3 proteins within the immune system, which may help reduce the underlying inflammation that causes asthma. This could give people with asthma more control over their daily symptoms.
Who may participate
It is important that all people with asthma have treatment options that work for them. Ensuring diversity within clinical trials from a broad range of people enables us to see how the potential medicine works in different types of people. We’ll be looking at factors like age, sex, and ethnicity to see if the treatment is effective for all people with moderate to severe asthma.
You may be eligible to participate if you*:
- Are between 18 and 70 years old
- Have been diagnosed with uncontrolled, moderate to severe asthma
- Experienced an asthma attack in the last 12 months that required taking steroids by mouth (as pills) for a total of 3 or more days, injection, or intravenously (into a vein)
Joining a clinical trial is an important and personal decision. We thank you for considering participation in this study.
*There may be additional requirements to participate. The trial team can help determine if you qualify to enrol in the trial.
What to expect
If this trial is a good fit for you and you agree to take part, you will receive 1 dose of the study medicine or a placebo at 3 visits given as injections by a healthcare professional. A placebo does not have any medicine in it, but it looks just like the medicine being studied. For this clinical trial, there will be a 5 out of 7 chance (71%) of you receiving the study medicine. You will continue to use your standard asthma medications, including emergency medications, if needed during the trial. The full trial will last approximately 38 weeks, and you will have about 10 visits in total.
Frequently Asked Questions
About the Clinical Trial
Asthma is a long-term respiratory condition that is often caused by underlying inflammation. People with asthma may experience symptoms such as wheezing, shortness of breath, chest tightness, and/or cough.
These symptoms can vary over time and change in intensity. Symptoms are often triggered by factors such as exercise, allergens or irritants, changes in weather, or a viral respiratory infection. They can also be caused by an overactive immune system.
Asthma can be difficult to treat long term. Patients with moderate to severe asthma do not respond well to standard inhaled treatments, and there is a need for more effective therapies to better control the symptoms (and causes) of asthma. If in the last 12 months you’ve needed to take steroids for worsening asthma, then this clinical trial might be a good option for you.
We are studying a type of steroid-free, biologic medicine called a trispecific that can target 3 proteins in your immune system at the same time. This may help reduce the underlying inflammation that causes asthma, which could give people with asthma more control over their daily symptoms.
Biologic medicines can target specific parts of your immune system. They are usually given as an injection, and if you have a condition like asthma, they may help to control the inflammation associated with asthma.
In the asthma clinical trial you will have a 5 out of 7 chance (71%) of receiving the study medicine and a 2 out of 7 chance (29%) of receiving a placebo.
A placebo looks like the medicine being studied but does not have any medicine in it. Researchers use a placebo to see if the study medicine works better or is safer than taking nothing.
Privacy, Stopping Participation, Costs, and Permission
The information you provide will not be shared with anyone who is not directly associated with the asthma clinical trial without your permission, except as required by law or as set forth in the Informed Consent Form, the document you would sign before participating in the clinical trial. The information collected during the trial is stored using codes that will not directly identify you.
Yes, you are free to leave the trial at any time. However, staying in a clinical trial until the end helps scientists and doctors collect enough information about a study medicine to see if it may help other people living with asthma.
No. [However, all clinical trial-related care and the study medicine will be provided at no cost. You will be reimbursed (paid back) for your transportation costs related to the clinical trial.] The trial team can provide more information about this.
No, your doctor does not have to give you permission to participate. However, you are welcome to talk to your doctor about participating in the asthma clinical trial. With your permission, the trial doctor can keep your regular doctor updated about your condition during the clinical trial.
About Clinical Trials
A clinical trial, also known as a research study, is a scientific study that evaluates the safety and effectiveness of a study medicine as well as how your body processes that medicine. Qualified doctors, nurses, and other medical professionals are responsible for conducting a clinical trial.
It is only through the completion of clinical trials that study medicines can be evaluated and, if proven safe and effective, be approved for a particular use.
During the informed consent process, the trial team will inform you about the possible benefits and risks of being in the trial. The team will closely monitor your symptoms and overall health throughout the trial and share any new information that becomes available.